Aquaporin water channels--from atomic structure to clinical medicine.

Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine.

Architecture and Selectivity in Aquaporins: 2.5 Å X-Ray Structure of Aquaporin Z

Aquaporins are a family of water and small molecule channels found in organisms ranging from bacteria to animals. One of these channels, the E. coli protein aquaporin Z (AqpZ), has been shown to selectively conduct only water at high rates. We have expressed, purified, crystallized, and solved the X-ray structure of AqpZ. The 2.5 A resolution structure of AqpZ suggests aquaporin selectivity res...

Selectivity and conductance among the glycerol and water conducting aquaporin family of channels.

The atomic structures of a transmembrane water plus glycerol conducting channel (GlpF), and now of aquaporin Z (AqpZ) from the same species, Escherichia coli, bring the total to three atomic resolution structures in the aquaporin (AQP) family. Members of the AQP family each assemble as tetramers of four channels. Common helical axes support a wider channel in the glycerol plus water channel par...

Molecular Physiology of Water Balance.

To the Editor: In their review article on water balance, Knepper et al. (April 2 issue)1 discuss water channels (aquaporins) in renal tubular cells. They omit mention of the critical role played by aquaporin-1 in microvascular endothelia. In the renal microvasculature, endothelial aquaporin-1 mediates the osmotic water efflux across descending vasa recta and is required for regulation of medull...

Changing the Physiological Response and Water Relationships in Sweet Pepper When Stopping the Activity of Root Aquaporin in Drought Stress

Aquaporins are the main proteins in the plasma membrane, which facilitates the movement of water, carbon dioxide, and other small soluble material through the membrane. The aim of this study was to investigate the role of root acuporine on the physiological, biochemical and biochemical changes and water relations under drought stress. For this purpose, a study was conducted in a completely rand...